Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation

Down syndrome (DS), a complex disorder that is caused by the trisomy of chromosome 21 (Hsa21), is a major cause of congenital heart defects (CHD). Interestingly, only about 50% of individuals with Hsa21 trisomy manifest CHD. Here we review the genetic basis of CHD in DS, focusing on genes that regul...

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Detalles Bibliográficos
Autores principales: Mollo, Nunzia, Scognamiglio, Roberta, Conti, Anna, Paladino, Simona, Nitsch, Lucio, Izzo, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918028/
https://www.ncbi.nlm.nih.gov/pubmed/36769235
http://dx.doi.org/10.3390/ijms24032918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918028/
https://www.ncbi.nlm.nih.gov/pubmed/36769235
http://dx.doi.org/10.3390/ijms24032918

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