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Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation

Down syndrome (DS), a complex disorder that is caused by the trisomy of chromosome 21 (Hsa21), is a major cause of congenital heart defects (CHD). Interestingly, only about 50% of individuals with Hsa21 trisomy manifest CHD. Here we review the genetic basis of CHD in DS, focusing on genes that regul...

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Detalles Bibliográficos
Autores principales:	Mollo, Nunzia, Scognamiglio, Roberta, Conti, Anna, Paladino, Simona, Nitsch, Lucio, Izzo, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918028/ https://www.ncbi.nlm.nih.gov/pubmed/36769235 http://dx.doi.org/10.3390/ijms24032918

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