ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study

Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential for DNA replication, repair and scaffold functions in the cytosol. Specific inhibition of PCNA in cancer cells is an attractive anti-cancer strategy. ATX-101 is a first-in-class drug targeting PCNA, primarily in cellul...

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Detalles Bibliográficos
Autores principales: Lemech, Charlotte Rose, Kichenadasse, Ganessan, Marschner, Jens-Peter, Alevizopoulos, Konstantinos, Otterlei, Marit, Millward, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918429/
https://www.ncbi.nlm.nih.gov/pubmed/36564469
http://dx.doi.org/10.1038/s41388-022-02582-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918429/
https://www.ncbi.nlm.nih.gov/pubmed/36564469
http://dx.doi.org/10.1038/s41388-022-02582-6

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