Cargando…

ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study

Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential for DNA replication, repair and scaffold functions in the cytosol. Specific inhibition of PCNA in cancer cells is an attractive anti-cancer strategy. ATX-101 is a first-in-class drug targeting PCNA, primarily in cellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lemech, Charlotte Rose, Kichenadasse, Ganessan, Marschner, Jens-Peter, Alevizopoulos, Konstantinos, Otterlei, Marit, Millward, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918429/ https://www.ncbi.nlm.nih.gov/pubmed/36564469 http://dx.doi.org/10.1038/s41388-022-02582-6

Ejemplares similares

ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
por: Gravina, Giovanni Luca, et al.
Publicado: (2022)

Novel Expanded Safe Zone for Reduction of Submental Fullness with ATX-101 Injection
por: Shridharani, Sachin M., et al.
Publicado: (2019)

An Assessment of the Reduction of Submental Fullness With ATX-101 (Deoxycholic Acid Injection) in the Expanded Safe Zone
por: Khan, Husnain, et al.
Publicado: (2023)

Abstract: Novel Expanded Safe Zone System for Treatment of Submental Fullness with ATX-101 (Deoxycholic Acid)
por: Shridharani, Sachin M., et al.
Publicado: (2017)

Alopecia after injection of ATX-101 for reduction of submental fat
por: Souyoul, Skylar, et al.
Publicado: (2017)

Abstract: Injection Adipocytolysis with ATX-101 (Deoxycholic Acid) for Body Contouring
por: Shridharani, Sachin M., et al.
Publicado: (2017)

Novel Surface Anatomic Landmarks of the Jowl to Guide Treatment with ATX-101
por: Shridharani, Sachin M.
Publicado: (2019)

Submental fat reduction using sequential treatment approach with cryolipolysis and ATX‐101
por: Jalian, H. Ray, et al.
Publicado: (2022)

PCNA regulates primary metabolism by scaffolding metabolic enzymes
por: Røst, Lisa M., et al.
Publicado: (2022)

Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA)
por: Seelinger, Mareike, et al.
Publicado: (2020)

A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)
por: Tokuhara, Yasunori, et al.
Publicado: (2015)

Abstract: Alopecia in Male Patients Treated with ATX-101 (Deoxycholic Acid) for Submental Fullness
por: Shridharani, Sachin M., et al.
Publicado: (2017)

Submental Area Treatment with ATX-101: Relationship of Mechanism of Action, Tissue Response, and Efficacy
por: Humphrey, Shannon, et al.
Publicado: (2022)

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA
por: Gilljam, Karin M., et al.
Publicado: (2012)

Intravenous ATP infusions can be safely administered in the home setting: a study in pre-terminal cancer patients
por: Beijer, Sandra, et al.
Publicado: (2007)

The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
por: Olaisen, Camilla, et al.
Publicado: (2018)

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
por: Søgaard, Caroline K., et al.
Publicado: (2019)

The PCNA interaction motifs revisited: thinking outside the PIP-box
por: Prestel, Andreas, et al.
Publicado: (2019)

Deoxycholate (ATX-101) Mixed with Lidocaine to Minimize Pain/Discomfort in Nonsurgical Treatment of Submental Fullness Appearance
por: Rauso, Raffaele
Publicado: (2018)

Early Experience in 100 Consecutive Patients With Injection Adipocytolysis for Neck Contouring With ATX-101 (Deoxycholic Acid)
por: Shridharani, Sachin M.
Publicado: (2017)

Improvement in Jowl Fat following ATX-101 Treatment: Results from a Single-Site Study
por: Shridharani, Sachin M.
Publicado: (2020)

Best Clinical Practices with ATX-101 for Submental Fat Reduction: Patient-related Factors and Physician Considerations
por: Teller, Craig F., et al.
Publicado: (2021)

Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide()
por: Gederaas, Odrun A., et al.
Publicado: (2014)

Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials
por: Dayan, Steven H, et al.
Publicado: (2018)

Identification of a novel, widespread, and functionally important PCNA-binding motif
por: Gilljam, Karin M., et al.
Publicado: (2009)

Hemodynamic effects of carbetocin administered as an intravenous bolus or infusion during cesarean delivery
por: Kwon, Kihyug, et al.
Publicado: (2020)

Abstract 33: Localized Injection Site Alopecia in Male Patients After Treatment of Submental Fat with ATX-101 (Deoxycholic Acid)
por: Shridharani, Sachin M., et al.
Publicado: (2018)

Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides
por: Yu, Yung-Luen, et al.
Publicado: (2013)

APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer
por: Søgaard, Caroline K., et al.
Publicado: (2018)

APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
por: Ræder, Synnøve Brandt, et al.
Publicado: (2018)

Reduction of Submental Fat Continues Beyond 28 Days After ATX-101 Treatment: Results From a Post hoc Analysis
por: Dover, Jeffrey S., et al.
Publicado: (2018)

Improvements in Submental Contour up to 3 Years After ATX-101: Efficacy and Safety Follow-Up of the Phase 3 REFINE Trials
por: Humphrey, Shannon, et al.
Publicado: (2021)

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
por: Nedal, Aina, et al.
Publicado: (2020)

Correction: Phase 1A/1B dose-escalation and -expansion study to evaluate the safety, pharmacokinetics, food effects and antitumor activity of pamiparib in advanced solid tumours
por: Lickliter, Jason D., et al.
Publicado: (2021)

Phase 1A/1B dose-escalation and -expansion study to evaluate the safety, pharmacokinetics, food effects and antitumor activity of pamiparib in advanced solid tumours
por: Lickliter, Jason D., et al.
Publicado: (2021)

Effect of intravenous dexmedetomidine administered as bolus or as bolus-plus-infusion on subarachnoid anesthesia with hyperbaric bupivacaine
por: Kavya, Upadhya R, et al.
Publicado: (2018)

Safety Profile of HTX-019 Administered as an Intravenous Infusion in Patients With Cancer: A Retrospective Analysis
por: Calcanes, George, et al.
Publicado: (2019)

Abstract 87: Improvements In Jowl Fat Following ATX-101 (Deoxycholic Acid) Injection: Updated Results From A Single-Site Study
por: Shridharani, Sachin M., et al.
Publicado: (2020)

Pharmacokinetics of Intravenously (DIZ101), Subcutaneously (DIZ102), and Intestinally (LCIG) Infused Levodopa in Advanced Parkinson Disease
por: Bergquist, Filip, et al.
Publicado: (2022)

Radiation Induced Leiomyosarcoma Three Decades After Treatment for Wilms’ Tumor
por: Khattak, Muhammad A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_k2g9hlu0voa655f28r9tolurdj