Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

Tailoring of the activity and specificity of proteases is critical for their utility across industrial, medical and research purposes. However, engineering or evolving protease catalysts is challenging and often labour intensive. Here, we describe a generic method to accelerate this process based on...

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Detalles Bibliográficos
Autores principales: Knyphausen, Philipp, Rangel Pereira, Mariana, Brear, Paul, Hyvönen, Marko, Jermutus, Lutz, Hollfelder, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918453/
https://www.ncbi.nlm.nih.gov/pubmed/36765057
http://dx.doi.org/10.1038/s41467-023-36099-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918453/
https://www.ncbi.nlm.nih.gov/pubmed/36765057
http://dx.doi.org/10.1038/s41467-023-36099-7

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