Cargando…

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis

The activation of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome triggers pyroptosis proinflammatory cell death in experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanisms of the inflammatory processes of microglia in EAE remain unclear...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Pei, Shanshan, Liu, Zhuhe, Ding, Yuewen, Qian, Tinglin, Wen, Haixia, Hsu, Ssu-Wei, Zhou, Zheyi, Zhang, Jun, Wang, Honghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918485/
https://www.ncbi.nlm.nih.gov/pubmed/36765034
http://dx.doi.org/10.1038/s41419-023-05621-6