IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis

The activation of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome triggers pyroptosis proinflammatory cell death in experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanisms of the inflammatory processes of microglia in EAE remain unclear...

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Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Pei, Shanshan, Liu, Zhuhe, Ding, Yuewen, Qian, Tinglin, Wen, Haixia, Hsu, Ssu-Wei, Zhou, Zheyi, Zhang, Jun, Wang, Honghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918485/
https://www.ncbi.nlm.nih.gov/pubmed/36765034
http://dx.doi.org/10.1038/s41419-023-05621-6

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