Oxygen transfer reaction of haloalkyl amides catalyzed by phenylboronic acid

Nitrile derivatives are important building blocks in organic synthesis. Herein, we report the serendipitous discovery of an oxygen transfer reaction that produces hydroxyalkyl nitriles from the sequential dehydration and hydrolysis of haloalkyl amides. Product yields of up to 91% were achieved, and...

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Detalles Bibliográficos
Autores principales: Sen, Abhijit, Muranaka, Atsuya, Ohno, Aya, Yamada, Yoichi M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918490/
https://www.ncbi.nlm.nih.gov/pubmed/36765132
http://dx.doi.org/10.1038/s42004-023-00824-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918490/
https://www.ncbi.nlm.nih.gov/pubmed/36765132
http://dx.doi.org/10.1038/s42004-023-00824-6

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