MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury

Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and subsequent activation of macrophage stimulator of...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Wu, Dongming, Zhou, Shun, Hu, Haoran, Li, Fei, Guan, Zhu, Zhan, Xinyu, Gao, Yiyun, Wang, Ping, Rao, Zhuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918524/
https://www.ncbi.nlm.nih.gov/pubmed/36765043
http://dx.doi.org/10.1038/s41420-023-01357-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918524/
https://www.ncbi.nlm.nih.gov/pubmed/36765043
http://dx.doi.org/10.1038/s41420-023-01357-6

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