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Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

Nup98 FG repeat domains comprise hydrophobic FG motifs linked through uncharged spacers. FG motifs capture nuclear transport receptors (NTRs) during nuclear pore complex (NPC) passage, confer inter-repeat cohesion, and condense the domains into a selective phase with NPC-typical barrier properties....

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Detalles Bibliográficos
Autores principales: Ng, Sheung Chun, Biswas, Abin, Huyton, Trevor, Schünemann, Jürgen, Reber, Simone, Görlich, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918544/
https://www.ncbi.nlm.nih.gov/pubmed/36765044
http://dx.doi.org/10.1038/s41467-023-36331-4