Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal type of cancer and the third leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in diagnosis, and rapid metastatic progression are the causes of high mortality in pancreatic cancer. Recent studies h...

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Detalles Bibliográficos
Autores principales: Hong, Eunji, Barczak, Wojciech, Park, Sujin, Heo, Jin Sun, Ooshima, Akira, Munro, Shonagh, Hong, Chang Pyo, Park, Jinah, An, Haein, Park, Joon Oh, Park, Seok Hee, La Thangue, Nick B., Kim, Seong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918730/
https://www.ncbi.nlm.nih.gov/pubmed/36765032
http://dx.doi.org/10.1038/s41419-023-05630-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918730/
https://www.ncbi.nlm.nih.gov/pubmed/36765032
http://dx.doi.org/10.1038/s41419-023-05630-5

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