Cargando…

Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal type of cancer and the third leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in diagnosis, and rapid metastatic progression are the causes of high mortality in pancreatic cancer. Recent studies h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Eunji, Barczak, Wojciech, Park, Sujin, Heo, Jin Sun, Ooshima, Akira, Munro, Shonagh, Hong, Chang Pyo, Park, Jinah, An, Haein, Park, Joon Oh, Park, Seok Hee, La Thangue, Nick B., Kim, Seong-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918730/ https://www.ncbi.nlm.nih.gov/pubmed/36765032 http://dx.doi.org/10.1038/s41419-023-05630-5

Ejemplares similares

Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models
por: Hong, Eunji, et al.
Publicado: (2020)

PRMT5 promotes cancer cell migration and invasion through the E2F pathway
por: Barczak, Wojciech, et al.
Publicado: (2020)

Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor
por: Park, Jiyoung, et al.
Publicado: (2022)

Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
por: Choi, Sung Hee, et al.
Publicado: (2023)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells
por: An, Haein, et al.
Publicado: (2021)

Linking H1 with chromatin and growth control
por: Munro, Shonagh, et al.
Publicado: (2017)

Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells
por: Pang, Kyoungwha, et al.
Publicado: (2022)

Phosphorylation status at Smad3 linker region modulates transforming growth factor‐β‐induced epithelial‐mesenchymal transition and cancer progression
por: Ooshima, Akira, et al.
Publicado: (2019)

Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma
por: Malek, Ehsan, et al.
Publicado: (2023)

Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis
por: Coutts, Amanda S, et al.
Publicado: (2018)

Co-treatment with Vactosertib, a Novel, Orally Bioavailable Activin Receptor-like Kinase 5 Inhibitor, Suppresses Radiotherapy-induced Epithelial-to-mesenchymal Transition, Cancer Cell Stemness, and Lung Metastasis of Breast Cancer
por: Choi, Jiwon, et al.
Publicado: (2022)

Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling
por: Park, Jinah, et al.
Publicado: (2013)

Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling
por: Kim, Eunji, et al.
Publicado: (2020)

PRMT5 inhibitors on the (myeloma) road
por: Gulla, Annamaria, et al.
Publicado: (2018)

Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
por: Roworth, Alice Poppy, et al.
Publicado: (2019)

Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie's Disease
por: Song, Kang-Moon, et al.
Publicado: (2020)

Immune modulation underpins the anti‐cancer activity of HDAC inhibitors
por: Blaszczak, Wiktoria, et al.
Publicado: (2021)

ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer
por: Lee, Jihee, et al.
Publicado: (2022)

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor
por: Kim, Young-Woong, et al.
Publicado: (2012)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
por: Liu, Geng, et al.
Publicado: (2023)

Detection of PRMT1 inhibitors with stopped flow fluorescence
por: Qian, Kun, et al.
Publicado: (2018)

TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis
por: Park, Cheol Ho, et al.
Publicado: (2022)

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
por: Barczak, Wojciech, et al.
Publicado: (2023)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice
por: Park, Jin-hong, et al.
Publicado: (2015)

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein
por: Carr, Simon M, et al.
Publicado: (2017)

Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
por: Krzyzanowski, Adrian, et al.
Publicado: (2022)

Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer
por: Brobbey, Charles, et al.
Publicado: (2023)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

Design and Synthesis of Novel PRMT1 Inhibitors and Investigation of Their Effects on the Migration of Cancer Cell
por: Wang, Caijiao, et al.
Publicado: (2022)

Deciphering the molecular mechanisms underlying the plasma membrane targeting of PRMT8
por: Park, Sang-Won, et al.
Publicado: (2019)

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer
por: Liu, Shuangjie, et al.
Publicado: (2022)

Reducing tumor invasiveness by ramucirumab and TGF‐β receptor kinase inhibitor in a diffuse‐type gastric cancer patient‐derived cell model
por: Lee, Song‐Yi, et al.
Publicado: (2021)

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
por: Nakayama, Kazuhide, et al.
Publicado: (2018)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners
por: Kim, Dong-Il, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eh7qip4i5knghr08g5vqb0j23r