The Quantification of Paclitaxel and Its Two Major Metabolites in Biological Samples by HPLC-MS/MS and Its Application in a Pharmacokinetic and Tumor Distribution Study in Xenograft Nude Mouse

A rapid and sensitive high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was developed for the quantification of Paclitaxel (PTX), 6α-hydroxypaclitaxel (6α-OHP), and p-3′-hydroxypaclitaxel (3′-OHP) in mouse plasma and tumor tissue. The analytes were separated using a...

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Detalles Bibliográficos
Autores principales: Huang, Haijin, Huang, Haolin, Sun, Yongbing, Liu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919154/
https://www.ncbi.nlm.nih.gov/pubmed/36770692
http://dx.doi.org/10.3390/molecules28031027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919154/
https://www.ncbi.nlm.nih.gov/pubmed/36770692
http://dx.doi.org/10.3390/molecules28031027

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