A New Regioselective Synthesis of the Cysteine-Rich Peptide Linaclotide

Linaclotide is a 14-amino acid residue peptide approved by the FDA for the treatment of irritable bowel syndrome with constipation (IBS-C), which activates guanylate cyclase C to accelerate intestinal transit. Here we show a new method for the synthesis of linaclotide through the completely selectiv...

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Detalles Bibliográficos
Autores principales: Qiu, Zhonghao, Dai, Xiandong, Fan, Chongxu, Cao, Ying, Lv, Zirui, Liang, Xingyong, Meng, Fanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919235/
https://www.ncbi.nlm.nih.gov/pubmed/36770675
http://dx.doi.org/10.3390/molecules28031007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919235/
https://www.ncbi.nlm.nih.gov/pubmed/36770675
http://dx.doi.org/10.3390/molecules28031007

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