A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide—A Comparative Study

Brucine (BRU) and brucine N-oxide (BNO) are prominent, bioactive, and toxic alkaloids in crude and processed Semen Strychni. Studies have demonstrated that BRU and BNO possess comprehensive pharmacological activities, such as anti-inflammatory and analgesic. In this context, a comparative study of B...

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Detalles Bibliográficos
Autores principales: Gao, Yan, Guo, Lin, Han, Ying, Zhang, Jingpu, Dai, Zhong, Ma, Shuangcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919335/
https://www.ncbi.nlm.nih.gov/pubmed/36771007
http://dx.doi.org/10.3390/molecules28031341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919335/
https://www.ncbi.nlm.nih.gov/pubmed/36771007
http://dx.doi.org/10.3390/molecules28031341

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