Cargando…

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Trypanosoma brucei is a species of kinetoplastid causing sleeping sickness in humans and nagana in cows and horses. One of the peculiarities of this species of parasites is represented by their redox metabolism. One of the proteins involved in this redox machinery is the monothiol glutaredoxin 1 (1C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Favaro, Annagiulia, Bolcato, Giovanni, Comini, Marcelo A., Moro, Stefano, Bellanda, Massimo, Sturlese, Mattia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919793/ https://www.ncbi.nlm.nih.gov/pubmed/36770941 http://dx.doi.org/10.3390/molecules28031276

Ejemplares similares

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region
por: Sturlese, Mattia, et al.
Publicado: (2018)

Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp
por: Li, Lenong, et al.
Publicado: (2010)

Evolution and Cellular Function of Monothiol Glutaredoxins: Involvement in Iron-Sulphur Cluster Assembly
por: Vilella, Felipe, et al.
Publicado: (2004)

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans
por: Attarian, Rodgoun, et al.
Publicado: (2018)

The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus
por: Misslinger, Matthias, et al.
Publicado: (2019)

The Monothiol Glutaredoxin Grx4 Influences Iron Homeostasis and Virulence in Ustilago maydis
por: McCotter, Sean W., et al.
Publicado: (2023)

Sequence and structural characterization of Trx-Grx type of monothiol glutaredoxins from Ashbya gossypii
por: Yadav, Saurabh, et al.
Publicado: (2013)

Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides
por: Ukuwela, Ashwinie A., et al.
Publicado: (2017)

The monothiol glutaredoxin Grx4 influences thermotolerance, cell wall integrity, and Mpk1 signaling in Cryptococcus neoformans
por: Hu, Guanggan, et al.
Publicado: (2021)

Monothiol Glutaredoxins Function in Storing and Transporting [Fe(2)S(2)] Clusters Assembled on IscU Scaffold Proteins
por: Shakamuri, Priyanka, et al.
Publicado: (2012)

Erratum for Attarian et al., “The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans”
por: Attarian, Rodgoun, et al.
Publicado: (2019)

Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes
por: Alkafeef, Selma S., et al.
Publicado: (2020)

Comparing Fragment Binding PosesPrediction Using HSP90 as a Key Study: When Bound Water Makes the Difference
por: Bolcato, Giovanni, et al.
Publicado: (2020)

Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe–2S] cluster
por: Abdalla, Mohnad, et al.
Publicado: (2016)

New Insights into Key Determinants for Adenosine 1 Receptor Antagonists Selectivity Using Supervised Molecular Dynamics Simulations
por: Bolcato, Giovanni, et al.
Publicado: (2020)

Effect of the Monothiol Glutaredoxin GrxD on 2,4-Diacetylphloroglucinol Biosynthesis and Biocontrol Activity of Pseudomonas fluorescens 2P24
por: Dong, Qiuling, et al.
Publicado: (2022)

Revisiting the Allosteric Regulation of Sodium Cation on the Binding of Adenosine at the Human A(2A) Adenosine Receptor: Insights from Supervised Molecular Dynamics (SuMD) Simulations
por: Bissaro, Maicol, et al.
Publicado: (2019)

Can We Still Trust Docking Results? An Extension of the Applicability of DockBench on PDBbind Database
por: Bolcato, Giovanni, et al.
Publicado: (2019)

Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir
por: Bolcato, Giovanni, et al.
Publicado: (2020)

Shedding Light on the Molecular Recognition of Sub-Kilodalton Macrocyclic Peptides on Thrombin by Supervised Molecular Dynamics
por: Hassankalhori, Mahdi, et al.
Publicado: (2021)

Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332
por: Pavan, Matteo, et al.
Publicado: (2021)

Re-Exploring the Ability of Common Docking Programs to Correctly Reproduce the Binding Modes of Non-Covalent Inhibitors of SARS-CoV-2 Protease M(pro)
por: Bassani, Davide, et al.
Publicado: (2022)

Ribose and Non-Ribose A2A Adenosine Receptor Agonists: Do They Share the Same Receptor Recognition Mechanism?
por: Bolcato, Giovanni, et al.
Publicado: (2022)

A Deep-Learning Approach toward Rational Molecular Docking Protocol Selection
por: Jiménez-Luna, José, et al.
Publicado: (2020)

Monothiol and dithiol glutaredoxin-1 from Clostridium oremlandii: identification of domain-swapped structures by NMR, X-ray crystallography and HDX mass spectrometry
por: Lee, Kitaik, et al.
Publicado: (2020)

Drugging an undruggable pocket on KRAS
por: Kessler, Dirk, et al.
Publicado: (2019)

Genetic suppressors of Δgrx3 Δgrx4, lacking redundant multidomain monothiol yeast glutaredoxins, rescue growth and iron homeostasis
por: Li, Guichun, et al.
Publicado: (2022)

Inspecting the Mechanism of Fragment Hits Binding on SARS‐CoV‐2 M(pro) by Using Supervised Molecular Dynamics (SuMD) Simulations
por: Bissaro, Maicol, et al.
Publicado: (2021)

HT-SuMD: making molecular dynamics simulations suitable for fragment-based screening. A comparative study with NMR
por: Ferrari, Francesca, et al.
Publicado: (2020)

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei
por: Ortíz, Cecilia, et al.
Publicado: (2021)

Drugging the Undruggable: Advances on RAS Targeting in Cancer
por: Molina-Arcas, Miriam, et al.
Publicado: (2021)

Drugging the undruggables: exploring the ubiquitin system for drug development
por: Huang, Xiaodong, et al.
Publicado: (2016)

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
por: Wyllie, Susan, et al.
Publicado: (2016)

SUMOylation in Trypanosoma brucei
por: Klein, Cornelia Andrea, et al.
Publicado: (2013)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes
por: Moreno, S Andrea, et al.
Publicado: (2015)

A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ
por: Bolcato, Giovanni, et al.
Publicado: (2021)

Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable”
por: Hantschel, Oliver, et al.
Publicado: (2011)

Drugging the “undruggable” DNA-binding domain of STAT3
por: Zhang, Jian-Ting, et al.
Publicado: (2016)

The Future of Medicinal Chemistry, PROTAC, and Undruggable Drug Targets
por: Poso, Antti
Publicado: (2021)

Drugging the undruggable: Ross Cagan interviews Kevan Shokat
por: Cagan, Ross, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4u9tlpq6cil2ncs8f2u4ta7jbd