Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent a new therapeutic option. However, this breakthrough is complicated by selectivity issues since pyruvate kinase exists in four different isofo...

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Detalles Bibliográficos
Autores principales: Battisti, Umberto Maria, Gao, Chunixa, Akladios, Fady, Kim, Woonghee, Yang, Hong, Bayram, Cemil, Bolat, Ismail, Kiliclioglu, Metin, Yuksel, Nursena, Tozlu, Ozlem Ozdemir, Zhang, Cheng, Sebhaoui, Jihad, Iqbal, Shazia, Shoaie, Saeed, Hacimuftuoglu, Ahmet, Yildirim, Serkan, Turkez, Hasan, Uhlen, Mathias, Boren, Jan, Mardinoglu, Adil, Grøtli, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919951/
https://www.ncbi.nlm.nih.gov/pubmed/36771285
http://dx.doi.org/10.3390/nu15030577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919951/
https://www.ncbi.nlm.nih.gov/pubmed/36771285
http://dx.doi.org/10.3390/nu15030577

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