Cargando…

Chemical Modification of Auranofin Yields a New Family of Anticancer Drug Candidates: The Gold(I) Phosphite Analogues

A panel of four novel gold(I) complexes, inspired by the clinically established gold drug auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate), was prepared and characterized. All these compounds feature the replacement of the triethylphosphine ligand of the parent compo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cirri, Damiano, Geri, Andrea, Massai, Lara, Mannelli, Michele, Gamberi, Tania, Magherini, Francesca, Becatti, Matteo, Gabbiani, Chiara, Pratesi, Alessandro, Messori, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920260/ https://www.ncbi.nlm.nih.gov/pubmed/36770719 http://dx.doi.org/10.3390/molecules28031050

Ejemplares similares

Auranofin and its analogs as prospective agents for the treatment of colorectal cancer
por: Massai, Lara, et al.
Publicado: (2022)

Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt(3))I: A Theoretical and Experimental Study
por: Tolbatov, Iogann, et al.
Publicado: (2020)

Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study
por: Magherini, Francesca, et al.
Publicado: (2018)

Au(2)phen and Auoxo6, Two Dinuclear Oxo-Bridged Gold(III) Compounds, Induce Apoptotic Signaling in Human Ovarian A2780 Cancer Cells
por: Gorini, Giulia, et al.
Publicado: (2021)

Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System
por: Cirri, Damiano, et al.
Publicado: (2020)

Cyclodextrin Inclusion Complexes of Auranofin and Its Iodido Analog: A Chemical and Biological Study
por: Cirri, Damiano, et al.
Publicado: (2021)

Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods
por: Massai, Lara, et al.
Publicado: (2020)

Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
por: Menconi, Alessio, et al.
Publicado: (2021)

The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
por: Ghini, Veronica, et al.
Publicado: (2023)

Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation
por: Chiaverini, Lorenzo, et al.
Publicado: (2022)

Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs
por: Massai, Lara, et al.
Publicado: (2022)

The effects of two gold-N-heterocyclic carbene (NHC) complexes in ovarian cancer cells: a redox proteomic study
por: Massai, Lara, et al.
Publicado: (2022)

Selection and characterization of a human ovarian cancer cell line resistant to auranofin
por: Landini, Ida, et al.
Publicado: (2017)

Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness
por: Gamberi, Tania, et al.
Publicado: (2021)

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules
por: Binacchi, Francesca, et al.
Publicado: (2020)

Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)
por: Chiappetta, Giovanni, et al.
Publicado: (2022)

Mechanistic Evaluations of the Effects of Auranofin Triethylphosphine Replacement with a Trimethylphosphite Moiety
por: Ronga, Luisa, et al.
Publicado: (2023)

Evaluation of Auranofin Loading within Ferritin Nanocages
por: Lucignano, Rosanna, et al.
Publicado: (2022)

Protein Metalation by Medicinal Gold Compounds: Identification of the Main Features of the Metalation Process through ESI MS Experiments
por: Geri, Andrea, et al.
Publicado: (2023)

Highlights of New Strategies to Increase the Efficacy of Transition Metal Complexes for Cancer Treatments
por: Giorgi, Ester, et al.
Publicado: (2022)

Investigation of auranofin and gold-containing analogues antibacterial activity against multidrug-resistant Neisseria gonorrhoeae
por: Elkashif, Ahmed, et al.
Publicado: (2020)

Modular chiral gold(i) phosphite complexes
por: Delpont, Nicolas, et al.
Publicado: (2013)

The Adipokines in Cancer Cachexia
por: Mannelli, Michele, et al.
Publicado: (2020)

A Metabolic Change towards Fermentation Drives Cancer Cachexia in Myotubes
por: Mannelli, Michele, et al.
Publicado: (2021)

The gold complex auranofin: new perspectives for cancer therapy
por: Abdalbari, Farah H., et al.
Publicado: (2021)

A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin
por: Marzo, Tiziano, et al.
Publicado: (2020)

Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity
por: Ferraro, Giarita, et al.
Publicado: (2021)

Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study
por: Tolbatov, Iogann, et al.
Publicado: (2022)

Gold(III) Compounds as New Family of Anticancer Drugs
por: Messori, Luigi, et al.
Publicado: (2003)

Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates
por: Massai, Lara, et al.
Publicado: (2021)

Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs
por: Fernandez-Vega, Lauren, et al.
Publicado: (2020)

An unprecedented palladium-arsenic catalytic cycle for nitriles hydration
por: Cirri, Damiano, et al.
Publicado: (2023)

Adiponectin in Myopathies
por: Gamberi, Tania, et al.
Publicado: (2019)

Fellows’ Hypo Phosphites
Publicado: (1880)

The Kinetics and Mechanism of the Reaction Between Serum Albumin and Auranofin (and its Isopropyl Analogue) In Vitro
por: Roberts, Jacqueline R., et al.
Publicado: (1994)

Medicinal Hypervalent Tellurium Prodrugs Bearing Different Ligands: A Comparative Study of the Chemical Profiles of AS101 and Its Halido Replaced Analogues
por: Chiaverini, Lorenzo, et al.
Publicado: (2022)

Gold-Induced Structural Switch of Cys34 in Albumin: Comparison of Auranofin With Aurothiomalate
por: Christodoulou, John, et al.
Publicado: (1994)

Cyclic Voltammetry of Auranofin
por: Mohamed, Ahmed A., et al.
Publicado: (1999)

Adiponectin Signaling Pathways in Liver Diseases
por: Gamberi, Tania, et al.
Publicado: (2018)

tert-Butylaminium phosphite
por: Jian, Fang-Fang, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ptt9bpouhb8lm9evcbdplqb324