Cargando…

Design, Synthesis and Biological Evaluation of Conjugates of 3-O-Descladinose-azithromycin and Nucleobases against rRNA A2058G- or A2059G-Mutated Strains

Structurally unrelated antibiotics MLS(B) (macrolide-lincosamide-streptogramin B) compromised with clinically resistant pathogens because of the cross-resistance resulting from the structural modification of rRNA A2058. The structure–activity relationships of a novel 3-O-descladinose azithromycin ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lian, Xiaotian, Liu, Wentian, Fan, Bingzhi, Yu, Mingjia, Liang, Jianhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920417/ https://www.ncbi.nlm.nih.gov/pubmed/36770992 http://dx.doi.org/10.3390/molecules28031327

Ejemplares similares

Evaluation of the accuracy of molecular assays targeting the mutation A2059G for detecting high-level azithromycin resistance in Neisseria gonorrhoeae: a systematic review and meta-analysis
por: Wang, Feng, et al.
Publicado: (2018)

High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis
por: Lu, Haikong, et al.
Publicado: (2015)

COLLABORATION AGREEMENT KE2059/TE
por: THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS OF THE POLISH ACADEMY OF SCIENCES, POLAND, et al.
Publicado: (2012)

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes
por: Jalava, Jari, et al.
Publicado: (2004)

Automatic delay compensation (PS/RF-LL 2059)
por: Blas, F, et al.
Publicado: (1995)

Automatic delay compensation (PS/RF-LL 2059)
por: Blas, F, et al.
Publicado: (1995)

COLLABORATION AGREEMENT KE2058/TE
por: THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLAER PHYSICS OF THE ACADEMY OF SCIENCES, POLAND, et al.
Publicado: (2012)

Increases in the Macrolide Resistance of Mycoplasma genitalium and the Emergence of the A2058T Mutation in the 23S rRNA Gene: Clonal Spread?
por: Piñeiro, Luis, et al.
Publicado: (2022)

Molecular dynamics simulations suggest why the A2058G mutation in 23S RNA results in bacterial resistance against clindamycin
por: Kulczycka-Mierzejewska, Katarzyna, et al.
Publicado: (2018)

Symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems
por: Boncel, Sławomir, et al.
Publicado: (2010)

2059. Antimicrobial Stewardship of Community Parenteral Antimicrobial Therapy: A Health System Approach
por: Buckel, Whitney R, et al.
Publicado: (2019)

Pyrene–nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies
por: Jabłoński, Artur, et al.
Publicado: (2017)

Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition
por: Mikalkėnas, Algirdas, et al.
Publicado: (2018)

2058 miRNA manipulation to improve CFTR correction in cystic fibrosis
por: Harris, William Thomas, et al.
Publicado: (2018)

Preclinical efficacy of the Wnt/β-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors
por: Braggio, Danielle Almeida, et al.
Publicado: (2022)

A Quantum-Mechanical Looking Behind the Scene of the Classic G·C Nucleobase Pairs Tautomerization
por: Brovarets', Ol'ha O., et al.
Publicado: (2020)

Nucleobase–Guanidiniocarbonyl-Pyrrole Conjugates as Novel Fluorimetric Sensors for Single Stranded RNA
por: Ban, Željka, et al.
Publicado: (2017)

Flexibility and Preorganization of Fluorescent Nucleobase-Pyrene Conjugates Control DNA and RNA Recognition
por: Ban, Željka, et al.
Publicado: (2020)

2058: Are atrial fibrillation patient-reported outcomes associated with person and environment characteristics?
por: Gleason, Kelly, et al.
Publicado: (2018)

2058. Patient Satisfaction Not Impacted by Antibiotic Prescribing for Viral Upper Respiratory Infections
por: Ray, Michael J, et al.
Publicado: (2019)

The Synergistic Activity of Bortezomib and TIC10 against A2058 Melanoma Cells
por: Takács, Angéla, et al.
Publicado: (2021)

Genome and catabolic subproteomes of the marine, nutritionally versatile, sulfate-reducing bacterium Desulfococcus multivorans DSM 2059
por: Dörries, Marvin, et al.
Publicado: (2016)

Haplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation
por: von Salomé, Jenny, et al.
Publicado: (2017)

Synthesis of novel conjugates of a saccharide, amino acids, nucleobase and the evaluation of their cell compatibility
por: Yuan, Dan, et al.
Publicado: (2014)

Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide
por: Yuan, Dan, et al.
Publicado: (2015)

PReS-FINAL-2058: Lipid peroxides, lipophuscin, sulfhydryl groups and TOS in children with JIA
por: Mazur Zielinska, H, et al.
Publicado: (2013)

Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells
por: Chang, Chi-Jen, et al.
Publicado: (2021)

Microhydration of Deprotonated Nucleobases
por: Wincel, Henryk
Publicado: (2016)

Food allergy and anaphylaxis – 2059. Mild symptoms induced by oral food challenge are not always associated with failed challenge results
por: Miura, Taro, et al.
Publicado: (2013)

PB2059: SUCCESSFUL OUTCOME OF A PATIENT WITH ADVANCED SYSTEMIC MASTOCYTOSIS TREATED WITH AZACYTIDINE AND AVAPRITINIB: A CASE REPORT
por: Saha, C., et al.
Publicado: (2022)

Food allergy and anaphylaxis – 2058. Elucidation of a 31 Kda cross-reactive kidney bean
por: Nagendra, Komarla, et al.
Publicado: (2013)

Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells
por: Kim, Areum Daseul, et al.
Publicado: (2013)

Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men
por: Kong, Fabian Y. S., et al.
Publicado: (2017)

G4 Structures in Control of Replication and Transcription of rRNA Genes
por: Havlová, Kateřina, et al.
Publicado: (2020)

Multinuclear Metal Nucleobase Complexes
por: Schreiber, A., et al.
Publicado: (1994)

Nucleobase modification by an RNA enzyme
por: Poudyal, Raghav R., et al.
Publicado: (2017)

Nucleoside Analogs with Fleximer Nucleobase
por: Chudinov, Mikhail V.
Publicado: (2020)

Nucleobase synthesis in interstellar ices
por: Oba, Yasuhiro, et al.
Publicado: (2019)

Intrinsic fluorescence of nucleobase crystals
por: Aizen, Ruth, et al.
Publicado: (2022)

2058. Comparison of Drug Resistance Rates of Mycobacterium tuberculosis by the Conventional Drug Susceptibility Test and Sequencing Method
por: Kim, Han-Sung
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ofm9dib238rphouba65d64h08h