Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors

Multi-target drugs (MTDs) are emerging alternatives to combination therapies. Since both histone deacetylases (HDACs) and cyclooxygenase-2 (COX-2) are known to be overexpressed in several cancer types, we herein report the design, synthesis, and biological evaluation of a library of dual HDAC-COX in...

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Detalles Bibliográficos
Autores principales: Bachmann, Luisa M., Hanl, Maria, Feller, Felix, Sinatra, Laura, Schöler, Andrea, Pietzsch, Jens, Laube, Markus, Hansen, Finn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920637/
https://www.ncbi.nlm.nih.gov/pubmed/36770730
http://dx.doi.org/10.3390/molecules28031061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920637/
https://www.ncbi.nlm.nih.gov/pubmed/36770730
http://dx.doi.org/10.3390/molecules28031061

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