Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT(6) and D(3)R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series

Salt bridge (SB, double-charge-assisted hydrogen bonds) formation is one of the strongest molecular non-covalent interactions in biological systems, including ligand–receptor complexes. In the case of G-protein-coupled receptors, such an interaction is formed by the conserved aspartic acid (D3.32) r...

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Detalles Bibliográficos
Autores principales: Grychowska, Katarzyna, Pietruś, Wojciech, Kulawik, Ludmiła, Bento, Ophélie, Satała, Grzegorz, Bantreil, Xavier, Lamaty, Frédéric, Bojarski, Andrzej J., Gołębiowska, Joanna, Nikiforuk, Agnieszka, Marin, Philippe, Chaumont-Dubel, Séverine, Kurczab, Rafał, Zajdel, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920808/
https://www.ncbi.nlm.nih.gov/pubmed/36770761
http://dx.doi.org/10.3390/molecules28031096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920808/
https://www.ncbi.nlm.nih.gov/pubmed/36770761
http://dx.doi.org/10.3390/molecules28031096

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