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A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation. Following nuclear import Jacob docks these s...

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Detalles Bibliográficos
Autores principales: Gomes, Guilherme M., Bär, Julia, Karpova, Anna, Kreutz, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921040/
https://www.ncbi.nlm.nih.gov/pubmed/36774487
http://dx.doi.org/10.1186/s13041-023-01012-2