Cargando…

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation. Following nuclear import Jacob docks these s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gomes, Guilherme M., Bär, Julia, Karpova, Anna, Kreutz, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921040/ https://www.ncbi.nlm.nih.gov/pubmed/36774487 http://dx.doi.org/10.1186/s13041-023-01012-2

Ejemplares similares

A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis
por: Spilker, Christina, et al.
Publicado: (2016)

What do we learn from the murine Jacob/Nsmf gene knockout for human disease?
por: Spilker, Christina, et al.
Publicado: (2016)

SAT-404 Effect of Nsmf Knockout upon Hypothalamic and Pituitary Gene Expression in the Nsmf KO Mouse
por: Louden, Erica, et al.
Publicado: (2019)

Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
por: Grochowska, Katarzyna M., et al.
Publicado: (2021)

Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus
por: Dieterich, Daniela C, et al.
Publicado: (2008)

Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
por: Pomytkin, Igor, et al.
Publicado: (2019)

Correction: Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus
por: Dieterich, Daniela C, et al.
Publicado: (2009)

Conserved contributions of NMDA receptor subtypes to synaptic responses in lamina II spinal neurons across early postnatal development
por: Mahmoud, Hadir, et al.
Publicado: (2020)

Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
por: Nomoto, Masanori, et al.
Publicado: (2023)

The nuclear lamina is a hub for the nuclear function of Jacob
por: Samer, Sebastian, et al.
Publicado: (2021)

Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons
por: Huang, Sun, et al.
Publicado: (2021)

ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice
por: Chacon, Jonathan, et al.
Publicado: (2019)

Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
por: Tsutsui, Shigeki, et al.
Publicado: (2022)

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice
por: Kasahara, Yoshiyuki, et al.
Publicado: (2019)

Rapid generation of conditional knockout mice using the CRISPR-Cas9 system and electroporation for neuroscience research
por: Nishizono, Hirofumi, et al.
Publicado: (2021)

Molecular mechanisms of NMDA excitotoxicity in the retina
por: Dvoriantchikova, Galina, et al.
Publicado: (2023)

Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia
por: Kobayashi, Katsunori, et al.
Publicado: (2018)

Reward‐enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention‐deficit/hyperactivity disorder
por: Ide, Soichiro, et al.
Publicado: (2018)

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
por: Black, Stefanie A. G., et al.
Publicado: (2014)

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein
por: Goloborshcheva, Valeria V., et al.
Publicado: (2020)

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
por: Han, Dae Hee, et al.
Publicado: (2021)

Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice
por: Nakajima, Ryuichi, et al.
Publicado: (2020)

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors
por: Gomes, Guilherme Monteiro, et al.
Publicado: (2014)

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death
por: Brennan-Minnella, A M, et al.
Publicado: (2013)

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death
por: Brennan-Minnella, A M, et al.
Publicado: (2013)

Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death
por: Belousov, Andrei B., et al.
Publicado: (2016)

Ablation of microglia does not alter circadian rhythm of locomotor activity
por: Matsui, Futaba, et al.
Publicado: (2023)

Microglia attenuate the kainic acid‐induced death of hippocampal neurons in slice cultures
por: Araki, Tasuku, et al.
Publicado: (2019)

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
por: Khosravani, Houman, et al.
Publicado: (2008)

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
por: Khosravani, Houman, et al.
Publicado: (2009)

Melanopsin(+)RGCs Are fully Resistant to NMDA-Induced Excitotoxicity
por: Vidal-Villegas, Beatriz, et al.
Publicado: (2019)

The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
por: Yang, Xiaorong, et al.
Publicado: (2017)

NSMF promotes the replication stress-induced DNA damage response for genome maintenance
por: Ju, Min Kyung, et al.
Publicado: (2021)

Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity
por: Yakoub, Kamal M., et al.
Publicado: (2019)

Induced neuronal activity does not attenuate amyloid beta‐induced synaptic loss in vitro
por: Kono, Rena, et al.
Publicado: (2019)

Bee honey protects astrocytes against oxidative stress: A preliminary in vitro investigation
por: Ali, Amira Mohammed, et al.
Publicado: (2019)

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity
por: Wu, Yu, et al.
Publicado: (2017)

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
por: Yang, Le, et al.
Publicado: (2014)

Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling
por: Minnella, Angela M., et al.
Publicado: (2018)

Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation
por: Gadotti, Vinicius M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_87ufqrh66md9i93j7dkv96989q