Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR(T790M)/BRAF(V600E) Pathways

Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We present here the development of a novel series of 5-chloro-indole-2-carboxylate 3a–e, 4a–c and pyrrolo[3,4-b]indol-3-ones 5a–c derivatives as...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921301/
https://www.ncbi.nlm.nih.gov/pubmed/36770936
http://dx.doi.org/10.3390/molecules28031269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921301/
https://www.ncbi.nlm.nih.gov/pubmed/36770936
http://dx.doi.org/10.3390/molecules28031269

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