Cargando…

Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?

BACKGROUND: Genomic testing has enhanced pre-surgical decision making for cytologically indeterminate thyroid nodules, but there remains uncertainty regarding RAS mutations. The addition of extra genetic alterations to previous driver mutation panels has been shown to improve predictive value. This...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hudson, Thomas J., Pusztaszeri, Marc Philippe, Hier, Michael P., Forest, Veronique-Isabelle, Yang, Ji-Wei, Payne, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921308/ https://www.ncbi.nlm.nih.gov/pubmed/36774522 http://dx.doi.org/10.1186/s40463-022-00611-8

Ejemplares similares

Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?
por: Turkdogan, Sena, et al.
Publicado: (2020)

Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review
por: Hier, Jessica, et al.
Publicado: (2021)

The Mcgill thyroid nodule score – does it help with indeterminate thyroid nodules?
por: Varshney, Rickul, et al.
Publicado: (2015)

Molecular Testing for Thyroid Nodules: The Experience at McGill University Teaching Hospitals in Canada
por: Rajab, Mohannad, et al.
Publicado: (2022)

Coexisting Molecular Alterations Increase the Risk of Malignancy in Thyroid Nodules with Copy Number Alterations
por: Rajab, Mohannad, et al.
Publicado: (2022)

The McGill Thyroid Nodule Score’s (MTNS+) role in the investigation of thyroid nodules with benign ultrasound guided fine needle aspiration biopsies: a retrospective review
por: Khalife, Sarah, et al.
Publicado: (2016)

EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles
por: Elsherbini, Noha, et al.
Publicado: (2022)

Surgical Outcomes of Thyroid Nodules Positive for Gene Expression Alterations Using ThyroSeq V3 Genomic Classifier
por: Salameh, Samer, et al.
Publicado: (2022)

The Difference in Clinical Behavior of Gene Fusions Involving RET/PTC Fusions and THADA/IGF2BP3 Fusions in Thyroid Nodules
por: Tali, George, et al.
Publicado: (2023)

Molecular mutations as a possible factor for determining extent of thyroid surgery
por: Krasner, Joshua R., et al.
Publicado: (2019)

Effect of Having Concurrent Mutations on the Degree of Aggressiveness in Patients with Thyroid Cancer Positive for TERT Promoter Mutations
por: Alohali, Sama, et al.
Publicado: (2023)

Characteristics of PTEN Mutation in Thyroid Tumours: A Retrospective Chart Review
por: Bandargal, Saruchi, et al.
Publicado: (2023)

The role of repeat fine needle aspiration in the management of indeterminate thyroid nodules
por: Jooya, Alborz, et al.
Publicado: (2016)

BRAFV600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
por: Silver, Jennifer A., et al.
Publicado: (2021)

Prognostic Indicators of EIF1AX-Mutated Thyroid Tumor Malignancy and Cancer Aggressiveness
por: Bandargal, Saruchi, et al.
Publicado: (2022)

Prevalence and aggressiveness of papillary thyroid carcinoma in surgically-treated graves’ disease patients: a retrospective matched cohort study
por: You, Eunice, et al.
Publicado: (2019)

Preoperative vocal cord paralysis and its association with malignant thyroid disease and other pathological features
por: Kay-Rivest, Emily, et al.
Publicado: (2015)

Mutational status may supersede tumor size in predicting the presence of aggressive pathologic features in well differentiated thyroid cancer
por: Semsar-Kazerooni, Koorosh, et al.
Publicado: (2022)

Carcinoembryonic antigen levels correlated with advanced disease in medullary thyroid cancer
por: Turkdogan, Sena, et al.
Publicado: (2018)

Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice
por: Kakudo, Kennichi
Publicado: (2022)

The T4/T3 quotient as a risk factor for differentiated thyroid cancer: a case control study
por: Sasson, Mark, et al.
Publicado: (2017)

The effect of minor allele frequency on the likelihood of obtaining false positives
por: Tabangin, Meredith E, et al.
Publicado: (2009)

Malignancy Risk in RAS-Mutated Cytologically Indeterminate Thyroid Nodules: Real-World Clinical Experience
por: Lu, Joseph, et al.
Publicado: (2021)

Preoperative prediction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: a Canadian single-Centre experience
por: Larouche, Vincent, et al.
Publicado: (2020)

Indeterminate Thyroid Nodules With RAS Mutations Have Higher Rates of Malignancy When Multiple Non-Cystic Nodules or Irregular Borders Are Present
por: Bernuy, Mario Carlos C Rivera, et al.
Publicado: (2021)

Frozen section analysis and sentinel lymph node biopsy in well differentiated thyroid cancer
por: Jozaghi, Yelda, et al.
Publicado: (2013)

Significance of RAS Mutations in Thyroid Benign Nodules and Non-Medullary Thyroid Cancer
por: Marotta, Vincenzo, et al.
Publicado: (2021)

Thyroidectomy for Graves’ Disease Predicts Postoperative Neck Hematoma and Hypocalcemia: A North American cohort study
por: Mohtashami, Sadaf, et al.
Publicado: (2021)

Differentiation of benign and malignant thyroid nodules based on the proportion of sponge-like areas on ultrasonography: imaging-pathologic correlation
por: Kim, Jee Young, et al.
Publicado: (2015)

Benign and malignant thyroid nodules with autoimmune thyroiditis
por: Kassi, Georgia N., et al.
Publicado: (2022)

The variable phenotype and low-risk nature of RAS-positive thyroid nodules
por: Medici, Marco, et al.
Publicado: (2015)

Completion thyroidectomy: predicting bilateral disease
por: Ibrahim, Badr, et al.
Publicado: (2015)

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features
por: Delfim, Ricardo Luiz Costantin, et al.
Publicado: (2017)

Evaluation of natural smile: Golden proportion, RED or Golden percentage
por: Murthy, B. V. Sreenivasan, et al.
Publicado: (2008)

Is thyroid nodule volume predictive for malignancy?
por: Bestepe, Nagihan, et al.
Publicado: (2019)

Variations of BRAF mutant allele percentage in melanomas
por: Hélias-Rodzewicz, Zofia, et al.
Publicado: (2015)

A retrospective cohort study: do patients with graves’ disease need to be euthyroid prior to surgery?
por: Al Jassim, Abrar, et al.
Publicado: (2018)

Constitutional frequency of rare alleles of c-Ha-ras in breast cancer patients.
por: White, G. R., et al.
Publicado: (1988)

Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?
por: Hosseini, S., et al.
Publicado: (2016)

The relationship between upper airway collapse and the severity of obstructive sleep apnea syndrome: a chart review
por: Schwartz, Russell N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_huaioqabrg2lejk6gcccln3n0v