Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study

A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield. The principles of cheminformatics and computational chemist...

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Detalles Bibliográficos
Autores principales: Krochtová, Kristína, Halečková, Annamária, Janovec, Ladislav, Blizniaková, Michaela, Kušnírová, Katarína, Kožurková, Mária
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921529/
https://www.ncbi.nlm.nih.gov/pubmed/36770975
http://dx.doi.org/10.3390/molecules28031308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921529/
https://www.ncbi.nlm.nih.gov/pubmed/36770975
http://dx.doi.org/10.3390/molecules28031308

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