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Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study
A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield. The principles of cheminformatics and computational chemist...
Autores principales: | Krochtová, Kristína, Halečková, Annamária, Janovec, Ladislav, Blizniaková, Michaela, Kušnírová, Katarína, Kožurková, Mária |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921529/ https://www.ncbi.nlm.nih.gov/pubmed/36770975 http://dx.doi.org/10.3390/molecules28031308 |
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