Coumarin-Based Sulfonamide Derivatives as Potential DPP-IV Inhibitors: Pre-ADME Analysis, Toxicity Profile, Computational Analysis, and In Vitro Enzyme Assay

Recent research on dipeptidyl peptidase-IV (DPP-IV) inhibitors has made it feasible to treat type 2 diabetes mellitus (T2DM) with minimal side effects. Therefore, in the present investigation, we aimed to discover and develop some coumarin-based sulphonamides as potential DPP-IV inhibitors in light...

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Detalles Bibliográficos
Autores principales: Vawhal, Pallavi Kishor, Jadhav, Shailaja B., Kaushik, Sumit, Panigrahi, Kahnu Charan, Nayak, Chandan, Urmee, Humaira, Khan, Sharuk L., Siddiqui, Falak A., Islam, Fahadul, Eftekhari, Aziz, Alzahrani, Abdullah R., Azlina, Mohd Fahami Nur, Sarker, Md. Moklesur Rahman, Ibrahim, Ibrahim Abdel Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921777/
https://www.ncbi.nlm.nih.gov/pubmed/36770672
http://dx.doi.org/10.3390/molecules28031004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921777/
https://www.ncbi.nlm.nih.gov/pubmed/36770672
http://dx.doi.org/10.3390/molecules28031004

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