Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Cellular mesenchymal–epithelial transition factor (c-Met), an oncogenic transmembrane receptor tyrosine kinase (RTK), plays an essential role in cell proliferation during embryo development and liver regeneration. Thioredoxin reductase (TrxR) is overexpressed and constitutively active in most tumors...

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Detalles Bibliográficos
Autores principales: Hu, Jinhui, Chen, Li, Lu, Zhonghui, Yao, Han, Hu, Yunfei, Feng, Luanqi, Pang, Yanqing, Wu, Jia-Qiang, Yu, Zhiling, Chen, Wen-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921947/
https://www.ncbi.nlm.nih.gov/pubmed/36770971
http://dx.doi.org/10.3390/molecules28031304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921947/
https://www.ncbi.nlm.nih.gov/pubmed/36770971
http://dx.doi.org/10.3390/molecules28031304

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