Computational and Experimental Evidence for Templated Macrocyclization: The Role of a Hydrogen Bond Network in the Quantitative Dimerization of 24-Atom Macrocycles

In the absence of preorganization, macrocyclization reactions are often plagued by oligomeric and polymeric side products. Here, a network of hydrogen bonds was identified as the basis for quantitative yields of macrocycles derived from the dimerization of monomers. Oligomers and polymers were not o...

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Detalles Bibliográficos
Autores principales: Menke, Alexander J., Henderson, Nicholas C., Kouretas, Lola C., Estenson, Anne N., Janesko, Benjamin G., Simanek, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921993/
https://www.ncbi.nlm.nih.gov/pubmed/36770811
http://dx.doi.org/10.3390/molecules28031144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921993/
https://www.ncbi.nlm.nih.gov/pubmed/36770811
http://dx.doi.org/10.3390/molecules28031144

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