Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis

The aberrant differentiation of valvular interstitial cells (VICs) to osteogenic lineages promotes calcified aortic valves disease (CAVD), partly activated by potentially destructive hemodynamic forces. These involve Rho A/ROCK1 signaling, a mechano-sensing pathway. However, how Rho A/ROCK1 signalin...

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Detalles Bibliográficos
Autores principales: Liu, Huiruo, Yin, Hang, Wang, Zhen, Yuan, Qiuhuan, Xu, Feng, Chen, Yuguo, Li, Chuanbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922265/
https://www.ncbi.nlm.nih.gov/pubmed/36774349
http://dx.doi.org/10.1038/s41419-023-05642-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922265/
https://www.ncbi.nlm.nih.gov/pubmed/36774349
http://dx.doi.org/10.1038/s41419-023-05642-1

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