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Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis
The aberrant differentiation of valvular interstitial cells (VICs) to osteogenic lineages promotes calcified aortic valves disease (CAVD), partly activated by potentially destructive hemodynamic forces. These involve Rho A/ROCK1 signaling, a mechano-sensing pathway. However, how Rho A/ROCK1 signalin...
Autores principales: | Liu, Huiruo, Yin, Hang, Wang, Zhen, Yuan, Qiuhuan, Xu, Feng, Chen, Yuguo, Li, Chuanbao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922265/ https://www.ncbi.nlm.nih.gov/pubmed/36774349 http://dx.doi.org/10.1038/s41419-023-05642-1 |
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