Dual blockage of both PD-L1 and CD47 enhances the therapeutic effect of oxaliplatin and FOLFOX in CT-26 mice tumor model

Colorectal cancer is a poorly immunogenic. Such property can be reverted by using ICD. However, ICD inducers can also induce the expression of inhibitory checkpoint receptors CD47 and PD-L1 on tumor cells, making CRC tumors resistant to mainly CD8 T cell killing and macrophage-mediated phagocytosis....

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Detalles Bibliográficos
Autores principales: Alimohammadi, Reza, Mahmoodi Chalbatani, Ghanbar, Alimohammadi, Masoumeh, Ghaffari-Nazari, Haniyeh, Rahimi, Arezou, Mortaz, Esmail, Mossafa, Nariman, Boon, Louis, Jalali, Seyed Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922272/
https://www.ncbi.nlm.nih.gov/pubmed/36774400
http://dx.doi.org/10.1038/s41598-023-29363-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922272/
https://www.ncbi.nlm.nih.gov/pubmed/36774400
http://dx.doi.org/10.1038/s41598-023-29363-9

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