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Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex

The S. pombe orthologue of the human PAXT connection, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex that targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA...

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Detalles Bibliográficos
Autores principales:	Soni, Komal, Sivadas, Anusree, Horvath, Attila, Dobrev, Nikolay, Hayashi, Rippei, Kiss, Leo, Simon, Bernd, Wild, Klemens, Sinning, Irmgard, Fischer, Tamás
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922296/ https://www.ncbi.nlm.nih.gov/pubmed/36774373 http://dx.doi.org/10.1038/s41467-023-36402-6

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