HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

BACKGROUND: Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that this RNA-mediated negative control mechanism, considered a cornerstone of the ce...

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Detalles Bibliográficos
Autores principales: Namer, Lise Sarah, Harwig, Alex, Heynen, Stephan P., Das, Atze T., Berkhout, Ben, Kaempfer, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922466/
https://www.ncbi.nlm.nih.gov/pubmed/36774495
http://dx.doi.org/10.1186/s13578-023-00972-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922466/
https://www.ncbi.nlm.nih.gov/pubmed/36774495
http://dx.doi.org/10.1186/s13578-023-00972-1

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