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Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning
Pancreatic islet transplantation in diabetes is limited by requirements for systemic immunosuppression to prevent rejection. Chang et al. report a non-toxic bone marrow conditioning regimen targeting c-Kit that permits stable mixed hematopoietic chimerism across major histocompatibility complex barr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922474/ https://www.ncbi.nlm.nih.gov/pubmed/36351397 http://dx.doi.org/10.1016/j.celrep.2022.111615 |
| _version_ | 1784887543608639488 |
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| author | Chang, Charles A. Bhagchandani, Preksha Poyser, Jessica Velasco, Brenda J. Zhao, Weichen Kwon, Hye-Sook Meyer, Everett Shizuru, Judith A. Kim, Seung K. |
| author_facet | Chang, Charles A. Bhagchandani, Preksha Poyser, Jessica Velasco, Brenda J. Zhao, Weichen Kwon, Hye-Sook Meyer, Everett Shizuru, Judith A. Kim, Seung K. |
| author_sort | Chang, Charles A. |
| collection | PubMed |
| description | Pancreatic islet transplantation in diabetes is limited by requirements for systemic immunosuppression to prevent rejection. Chang et al. report a non-toxic bone marrow conditioning regimen targeting c-Kit that permits stable mixed hematopoietic chimerism across major histocompatibility complex barriers, promoting allotolerance to transplanted islets without systemic immunosuppression and durable diabetes correction. |
| format | Online Article Text |
| id | pubmed-9922474 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99224742023-02-12 Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning Chang, Charles A. Bhagchandani, Preksha Poyser, Jessica Velasco, Brenda J. Zhao, Weichen Kwon, Hye-Sook Meyer, Everett Shizuru, Judith A. Kim, Seung K. Cell Rep Article Pancreatic islet transplantation in diabetes is limited by requirements for systemic immunosuppression to prevent rejection. Chang et al. report a non-toxic bone marrow conditioning regimen targeting c-Kit that permits stable mixed hematopoietic chimerism across major histocompatibility complex barriers, promoting allotolerance to transplanted islets without systemic immunosuppression and durable diabetes correction. 2022-11-08 /pmc/articles/PMC9922474/ /pubmed/36351397 http://dx.doi.org/10.1016/j.celrep.2022.111615 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
| spellingShingle | Article Chang, Charles A. Bhagchandani, Preksha Poyser, Jessica Velasco, Brenda J. Zhao, Weichen Kwon, Hye-Sook Meyer, Everett Shizuru, Judith A. Kim, Seung K. Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title | Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title_full | Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title_fullStr | Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title_full_unstemmed | Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title_short | Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| title_sort | curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922474/ https://www.ncbi.nlm.nih.gov/pubmed/36351397 http://dx.doi.org/10.1016/j.celrep.2022.111615 |
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