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Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning
Pancreatic islet transplantation in diabetes is limited by requirements for systemic immunosuppression to prevent rejection. Chang et al. report a non-toxic bone marrow conditioning regimen targeting c-Kit that permits stable mixed hematopoietic chimerism across major histocompatibility complex barr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922474/ https://www.ncbi.nlm.nih.gov/pubmed/36351397 http://dx.doi.org/10.1016/j.celrep.2022.111615 |