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RANK signaling in osteoclast precursors results in a more permissive epigenetic landscape and sexually divergent patterns of gene expression

BACKGROUND: Sex is an important risk factor in the development of osteoporosis and other bone loss disorders, with women often demonstrating greater susceptibility than men. While variation in sex steroids, such as estradiol, accounts for much of the risk, there are likely additional non-endocrine f...

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Detalles Bibliográficos
Autores principales: Keever, Abigail L., Collins, Kathryn M., Clark, Rachel A., Framstad, Amber L., Ashley, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922499/
https://www.ncbi.nlm.nih.gov/pubmed/36788807
http://dx.doi.org/10.7717/peerj.14814