Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae

PTPN6 encodes SHP1, a protein tyrosine phosphatase with an essential role in immune cell function. SHP1 mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles the phenotype seen in motheaten mice that lack functional SHP1. To investigate the function of Shp1 i...

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Detalles Bibliográficos
Autores principales: Allers, Maaike, Bakker, Petra A., Hoeksma, Jelmer, Spaink, Herman P., den Hertog, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922729/
https://www.ncbi.nlm.nih.gov/pubmed/36645087
http://dx.doi.org/10.1242/dmm.049715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922729/
https://www.ncbi.nlm.nih.gov/pubmed/36645087
http://dx.doi.org/10.1242/dmm.049715

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