Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening

Overexpression of the HER2 protein in breast cancer patients is a predictor of poor prognosis and resistance to therapies. We used an inducible breast cancer transformation system that allows investigation of early molecular changes. HER2 overexpression to similar levels as those observed in a subty...

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Detalles Bibliográficos
Autores principales: Hayat, Ateequllah, Carter, Edward P., King, Hamish W., Ors, Aysegul, Doe, Aaron, Teijeiro, Saul A., Charrot, Sarah, Godinho, Susana, Cutillas, Pedro, Mohammed, Hisham, Grose, Richard P., Ficz, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922733/
https://www.ncbi.nlm.nih.gov/pubmed/36661191
http://dx.doi.org/10.1242/dmm.049894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922733/
https://www.ncbi.nlm.nih.gov/pubmed/36661191
http://dx.doi.org/10.1242/dmm.049894

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