Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase

Heat shock protein 90 (Hsp90) is known to mediate heme insertion and activation of heme-deficient neuronal nitric oxide (NO) synthase (apo-nNOS) in cells by a highly dynamic interaction that has been extremely difficult to study mechanistically with the use of subcellular systems. In that the heme c...

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Detalles Bibliográficos
Autores principales: Morishima, Yoshihiro, Lau, Miranda, Pratt, William B., Osawa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922822/
https://www.ncbi.nlm.nih.gov/pubmed/36596358
http://dx.doi.org/10.1016/j.jbc.2022.102856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922822/
https://www.ncbi.nlm.nih.gov/pubmed/36596358
http://dx.doi.org/10.1016/j.jbc.2022.102856

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