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The penultimate step of proteasomal ATPase assembly is mediated by a switch dependent on the chaperone Nas2

The proteasome holoenzyme is a complex molecular machine that degrades most proteins. In the proteasome holoenzyme, six distinct ATPase subunits (Rpt1 through Rpt6) enable protein degradation by injecting protein substrates into it. Individual Rpt subunits assemble into a heterohexameric “Rpt ring”...

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Detalles Bibliográficos
Autores principales: Sekaran, Suganya, Park, Soyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922823/
https://www.ncbi.nlm.nih.gov/pubmed/36621624
http://dx.doi.org/10.1016/j.jbc.2023.102870