Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells

INTRODUCTION: Although the engineering of T cells to co-express immunostimulatory cytokines has been shown to enhance the therapeutic efficacy of adoptive T cell therapy, the uncontrolled systemic release of potent cytokines can lead to severe adverse effects. To address this, we site-specifically i...

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Detalles Bibliográficos
Autores principales: Kim, Segi, Park, Cho I, Lee, Sunhwa, Choi, Hyeong Ryeol, Kim, Chan Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923015/
https://www.ncbi.nlm.nih.gov/pubmed/36793716
http://dx.doi.org/10.3389/fimmu.2023.1062365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923015/
https://www.ncbi.nlm.nih.gov/pubmed/36793716
http://dx.doi.org/10.3389/fimmu.2023.1062365

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