MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

BACKGROUND: The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion and dysfunction of T cells in the tumor microenv...

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Detalles Bibliográficos
Autores principales: Morimoto, Yoshihiro, Yamashita, Nami, Daimon, Tatsuaki, Hirose, Haruka, Yamano, Shizuka, Haratake, Naoki, Ishikawa, Satoshi, Bhattacharya, Atrayee, Fushimi, Atsushi, Ahmad, Rehan, Takahashi, Hidekazu, Dashevsky, Olga, Mitsiades, Constantine, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923360/
https://www.ncbi.nlm.nih.gov/pubmed/36754452
http://dx.doi.org/10.1136/jitc-2022-006238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923360/
https://www.ncbi.nlm.nih.gov/pubmed/36754452
http://dx.doi.org/10.1136/jitc-2022-006238

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