Cargando…

SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck

[Image: see text] A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell entry during COVID-19 infection and can also independently disrupt cellular functions. Here, we found that S12...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tillman, Tommy S., Chen, Qiang, Bondarenko, Vasyl, Coleman, Jonathan A., Xu, Yan, Tang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923440/ https://www.ncbi.nlm.nih.gov/pubmed/36745901 http://dx.doi.org/10.1021/acschemneuro.2c00610

Ejemplares similares

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization
por: Bondarenko, Vasyl, et al.
Publicado: (2023)

Sulfonium Ligands of the α7 nAChR
por: Horenstein, Nicole A., et al.
Publicado: (2021)

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
por: Lin, Bo, et al.
Publicado: (2016)

Vagal α7nAChR signaling regulates α7nAChR(+)Sca1(+) cells during lung injury repair
por: Chen, Xiaoyan, et al.
Publicado: (2020)

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
por: Dutertre, Sébastien, et al.
Publicado: (2007)

The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis
por: Hu, Song, et al.
Publicado: (2021)

Impact of SARS-CoV-2 spike protein on α7 nicotinic acetylcholine receptor in cells
por: Tillman, Tommy S., et al.
Publicado: (2022)

α7nAchR/NMDAR coupling affects NMDAR function and object recognition
por: Li, Shupeng, et al.
Publicado: (2013)

Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons
por: Getz, Angela M., et al.
Publicado: (2017)

Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages
por: Liu, Etta Y.L., et al.
Publicado: (2020)

Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure
por: Zambrano, Cristian A, et al.
Publicado: (2015)

Regulation of RIC-3 and of nAChR expression
por: Ben-David, Yael, et al.
Publicado: (2016)

α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Escherichia coli
por: Liu, Yanli, et al.
Publicado: (2020)

Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea
por: Vyas, Pankhuri, et al.
Publicado: (2020)

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs
por: Ho, Thao N.T., et al.
Publicado: (2021)

Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking
por: Chen, Tingting, et al.
Publicado: (2020)

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M(2) Receptors
por: Zlotos, Darius P., et al.
Publicado: (2014)

SARS-CoV-2 S1 spike protein peptides inhibit alpha 7 nAChRs and are counteracted by a PAM at alpha 7
por: Farley, Joseph, et al.
Publicado: (2022)

E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation
por: Wang, Qixin, et al.
Publicado: (2020)

Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas
por: Shen, Yujie, et al.
Publicado: (2022)

In silico studies of ASEM analogues targeting α7-nAChR and experimental verification
por: Zhou, Yang, et al.
Publicado: (2021)

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking
por: Rudell, Jolene Chang, et al.
Publicado: (2020)

Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability
por: Henderson, Brandon J, et al.
Publicado: (2017)

Ion permeation through neuronal nAChR ion channel
por: Krüger, Jens, et al.
Publicado: (2010)

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
por: Kalkman, Hans O., et al.
Publicado: (2016)

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis
por: Liu, Yuan, et al.
Publicado: (2021)

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients
por: Courties, Alice, et al.
Publicado: (2021)

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation
por: Wang, Qixin, et al.
Publicado: (2020)

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site
por: Gulsevin, Alican, et al.
Publicado: (2021)

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials
por: Yang, Taoyi, et al.
Publicado: (2017)

Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus
por: Tang, XiaoHong, et al.
Publicado: (2018)

Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats
por: Zhou, Li, et al.
Publicado: (2021)

Total synthesis of the natural (−)-205B alkaloid and its activity toward α7 nAChRs
por: Mazeh, Sara, et al.
Publicado: (2022)

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR
por: Lin, Bo, et al.
Publicado: (2016)

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR
por: Pan, Si, et al.
Publicado: (2021)

Comparative functional expression of nAChR subtypes in rodent DRG neurons
por: Smith, Nathan J., et al.
Publicado: (2013)

Tribendimidine: Mode of Action and nAChR Subtype Selectivity in Ascaris and Oesophagostomum
por: Robertson, Alan P., et al.
Publicado: (2015)

RIC-3 expression and splicing regulate nAChR functional expression
por: Ben-David, Yael, et al.
Publicado: (2016)

The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression
por: Schaal, Courtney, et al.
Publicado: (2015)

Nicotinic-nAChR signaling mediates drug resistance in lung cancer
por: Cheng, Wan-Li, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9niuafe7gvfeh6dkjbluin4fj7