Cargando…

Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study

[Image: see text] Bisphenol A (BPA, 2,2-bis-(4-hydroxyphenyl)propane) is used as a precursor in the synthesis of polycarbonate and epoxy plastics; however, its availability in the environment is causing toxicity as an endocrine-disrupting chemical. Metabolism of BPA and their analogues (substitutes)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hermano Sampaio Dias, Artur, Yadav, Rolly, Mokkawes, Thirakorn, Kumar, Asheesh, Skaf, Munir S., Sastri, Chivukula V., Kumar, Devesh, de Visser, Sam P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923688/ https://www.ncbi.nlm.nih.gov/pubmed/36651185 http://dx.doi.org/10.1021/acs.inorgchem.2c03984

Ejemplares similares

Melatonin Activation by Cytochrome P450 Isozymes: How Does CYP1A2 Compare to CYP1A1?
por: Mokkawes, Thirakorn, et al.
Publicado: (2023)

Melatonin Activation by Human Cytochrome P450 Enzymes: A Comparison between Different Isozymes
por: Mokkawes, Thirakorn, et al.
Publicado: (2023)

Mechanism of Melatonin Metabolism by CYP1A1: What Determines the Bifurcation Pathways of Hydroxylation versus Deformylation?
por: Mokkawes, Thirakorn, et al.
Publicado: (2022)

Comparison of Bisphenol A and Bisphenol S Percutaneous Absorption and Biotransformation
por: Liu, Jiaying, et al.
Publicado: (2019)

Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450
por: Jia, Yue, et al.
Publicado: (2022)

Second Coordination Sphere Effects on the Mechanistic Pathways for Dioxygen Activation by a Ferritin: Involvement of a Tyr Radical and the Identification of a Cation Binding Site
por: Yeh, Chieh‐Chih George, et al.
Publicado: (2022)

Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes
por: Braun, Andreas, et al.
Publicado: (2012)

Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People
por: Khan, Burhan A., et al.
Publicado: (2018)

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
por: Shrestha, Riya, et al.
Publicado: (2018)

Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies
por: Schulz, Christian, et al.
Publicado: (2023)

Optimization of the in vitro oxidative biotransformation of glimepiride as a model substrate for cytochrome p450 using factorial design
por: Ruikar, Dipti B, et al.
Publicado: (2012)

Coupling and uncoupling mechanisms in the methoxythreonine mutant of cytochrome P450cam: a quantum mechanical/molecular mechanical study
por: Altarsha, Muhannad, et al.
Publicado: (2009)

Biotransformation of bisphenol A analogues by the biphenyl-degrading bacterium Cupriavidusbasilensis - a structure-biotransformation relationship
por: Zühlke, Marie-Katherin, et al.
Publicado: (2020)

A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
por: Mallinson, Sam J. B., et al.
Publicado: (2018)

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes
por: Kumar, Santosh, et al.
Publicado: (2012)

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems
por: Wheeler, Abigail M., et al.
Publicado: (2023)

How Is Substrate Halogenation Triggered by the Vanadium Haloperoxidase from Curvularia inaequalis?
por: Gérard, Emilie F., et al.
Publicado: (2023)

Biodegradation of Bisphenol A by Sphingobium sp. YC-JY1 and the Essential Role of Cytochrome P450 Monooxygenase
por: Jia, Yang, et al.
Publicado: (2020)

Correction to: Biotransformation of bisphenol a analogues by the biphenyl-degrading bacterium Cupriavidus basilensis - a structure-biotransformation relationship
por: Zühlke, Marie-Katherin, et al.
Publicado: (2021)

Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands
por: Presley, Christopher C., et al.
Publicado: (2019)

Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review
por: Loerracher, Ann-Kathrin, et al.
Publicado: (2021)

Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6
por: Sheludko, Y. V., et al.
Publicado: (2022)

Product Distributions of Cytochrome P450 OleT(JE) with Phenyl-Substituted Fatty Acids: A Computational Study
por: Lin, Yen-Ting, et al.
Publicado: (2021)

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s
por: Kashyap, Mahendra Pratap, et al.
Publicado: (2011)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis
por: Rao, P. S. S., et al.
Publicado: (2015)

Differences and Comparisons of the Properties and Reactivities of Iron(III)–hydroperoxo Complexes with Saturated Coordination Sphere
por: Faponle, Abayomi S, et al.
Publicado: (2015)

Lignin Biodegradation by a Cytochrome P450 Enzyme: A Computational Study into Syringol Activation by GcoA
por: Ali, Hafiz Saqib, et al.
Publicado: (2020)

Bioengineering of Cytochrome P450 OleT(JE): How Does Substrate Positioning Affect the Product Distributions?
por: Cantú Reinhard, Fabián G., et al.
Publicado: (2020)

Biotransformation of Bisphenol AF to Its Major Glucuronide Metabolite Reduces Estrogenic Activity
por: Li, Ming, et al.
Publicado: (2013)

Biotransformation of Phthalate Plasticizers and Bisphenol A by Marine-Derived, Freshwater, and Terrestrial Fungi
por: Carstens, Lena, et al.
Publicado: (2020)

NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
por: Schulz, Christian, et al.
Publicado: (2019)

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs
por: Liu, Kang‐Cheng, et al.
Publicado: (2017)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Intronic polymorphisms of cytochromes P450
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2010)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

Cytochromes P450, Oxygen, and Evolution
por: Lewis, David F.V., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_fqjvf4a7oeb6s1a8l4ctinoadp