METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey

[Image: see text] RNA methylation is a critical mechanism for regulating the transcription and translation of specific sequences or for eliminating unnecessary sequences during RNA maturation. METTL3, an RNA methyltransferase that catalyzes the transfer of a methyl group to the N(6)-adenosine of RNA...

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Detalles Bibliográficos
Autores principales: Fiorentino, Francesco, Menna, Martina, Rotili, Dante, Valente, Sergio, Mai, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923689/
https://www.ncbi.nlm.nih.gov/pubmed/36692498
http://dx.doi.org/10.1021/acs.jmedchem.2c01601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923689/
https://www.ncbi.nlm.nih.gov/pubmed/36692498
http://dx.doi.org/10.1021/acs.jmedchem.2c01601

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