Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action

[Image: see text] Screening of 25 analogs of Ebselen, diversified at the N-aromatic residue, led to the identification of the most potent inhibitors of Sporosarcina pasteurii urease reported to date. The presence of a dihalogenated phenyl ring caused exceptional activity of these 1,2-benzisoselenazo...

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Detalles Bibliográficos
Autores principales: Macegoniuk, Katarzyna, Tabor, Wojciech, Mazzei, Luca, Cianci, Michele, Giurg, Mirosław, Olech, Kamila, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Grabowiecka, Agnieszka, Mucha, Artur, Ciurli, Stefano, Berlicki, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923736/
https://www.ncbi.nlm.nih.gov/pubmed/36661843
http://dx.doi.org/10.1021/acs.jmedchem.2c01799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923736/
https://www.ncbi.nlm.nih.gov/pubmed/36661843
http://dx.doi.org/10.1021/acs.jmedchem.2c01799

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