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Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action
[Image: see text] Screening of 25 analogs of Ebselen, diversified at the N-aromatic residue, led to the identification of the most potent inhibitors of Sporosarcina pasteurii urease reported to date. The presence of a dihalogenated phenyl ring caused exceptional activity of these 1,2-benzisoselenazo...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923736/ https://www.ncbi.nlm.nih.gov/pubmed/36661843 http://dx.doi.org/10.1021/acs.jmedchem.2c01799 |