Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy

INTRODUCTION: Glucarpidase (CPG2) reduces the lethal toxicity of methotrexate (MTX) by rapid degradation. METHODS: In this study, a CPG2 population pharmacokinetics (popPK) analysis in healthy volunteers (phase 1 study) and a popPK-pharmacodynamics (popPK-PD) analysis in patients (phase 2 study, n =...

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Detalles Bibliográficos
Autores principales: Fukaya, Yutaka, Kimura, Toshimi, Hamada, Yukihiro, Yoshimura, Kenichi, Hiraga, Hiroaki, Yuza, Yuki, Ogawa, Atsushi, Hara, Junichi, Koh, Katsuyoshi, Kikuta, Atsushi, Koga, Yuhki, Kawamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924065/
https://www.ncbi.nlm.nih.gov/pubmed/36793598
http://dx.doi.org/10.3389/fonc.2023.1003633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924065/
https://www.ncbi.nlm.nih.gov/pubmed/36793598
http://dx.doi.org/10.3389/fonc.2023.1003633

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